Metabolism of quinine in man: identification of a major metabolite, and effects of smoking and rifampicin pretreatment.

@article{Wanwimolruk1995MetabolismOQ,
  title={Metabolism of quinine in man: identification of a major metabolite, and effects of smoking and rifampicin pretreatment.},
  author={Sompon Wanwimolruk and S M Wong and Hong Zhang and Philippe Coville and Robert J Walker},
  journal={The Journal of pharmacy and pharmacology},
  year={1995},
  volume={47 11},
  pages={957-63}
}
Our previous studies have shown that cigarette smoking and rifampicin pretreatment enhance the elimination of quinine, metabolism assumed, by analogy with quinidine, to be carried out by CYP3A (P450IIIA). This finding is unexpected since it has been shown that smoking induces the CYP1A rather than the CYP3A enzyme family, suggesting that the metabolism of quinine may be catalysed by CYP1A. Therefore, we conducted this study to identify possible quinine metabolites in human urine and to… CONTINUE READING

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