Metabolism of polychlorinated biphenyls by Gunn rats: identification and serum retention of catechol metabolites.

  title={Metabolism of polychlorinated biphenyls by Gunn rats: identification and serum retention of catechol metabolites.},
  author={K. Haraguchi and Y. Kato and N. Koga and M. Degawa},
  journal={Chemical research in toxicology},
  volume={17 12},
  • K. Haraguchi, Y. Kato, +1 author M. Degawa
  • Published 2004
  • Chemistry, Medicine
  • Chemical research in toxicology
  • The tissue distributions of persistent metabolites of polychlorinated biphenyls (PCBs) in Wistar rats and homozygous uridine diphosphate glucuronosyltransferase (UGT) deficient Gunn rats exposed to 2,4,5,2',5'-pentachlorobiphenyl (CB101) and the commercial PCB mixture, Kanechlor-500 (KC500), were investigated. After exposure to CB101, four hydroxy and two methylsulfonyl (MeSO2) metabolites were detected in liver, lung, kidney, blood, and adipose tissues. One was identified as 3',4'-(OH)2-2,4,5… CONTINUE READING
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