Metabolism of nicotine and induction of CYP1A forms in precision-cut rat liver and lung slices.

@article{Price2004MetabolismON,
  title={Metabolism of nicotine and induction of CYP1A forms in precision-cut rat liver and lung slices.},
  author={Roger J. Price and Anthony B. Renwick and D. Gerry Walters and Philip J. Young and Brian G Lake},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2004},
  volume={18 2},
  pages={179-85}
}
The aim of this study was to investigate xenobiotic metabolism and induction of cytochrome P450 (CYP) forms in precision-cut rat liver and lung slices, employing nicotine as a model compound. Freshly cut rat liver and lung slices metabolised nicotine to the major metabolite cotinine. Observed Km values for cotinine formation in liver and lung slices were 323 and 41.7 microM, respectively, with corresponding V(max) values of 47.2 and 3.21 pmol/min/mg protein, respectively. Rat liver and lung… CONTINUE READING

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