Metabolism of n-hexyl-homologues of delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in the mouse

@article{Brown2010MetabolismON,
  title={Metabolism of n-hexyl-homologues of delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in the mouse},
  author={N. K. Brown and David J. Harvey},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={13},
  pages={165-176}
}
  • N. K. Brown, D. Harvey
  • Published 1 July 1988
  • Biology, Chemistry
  • European Journal of Drug Metabolism and Pharmacokinetics
Summaryn-Hexyl-delta-8-tetrahydrocannabiol (n-hexyl-dclta-8-THC) andn-hexyl-delta-9-THC were synthesized by condensation of (1S)-cis-verbenol with 5-n-hexyl-1,3-dihydroxybenzene and administered intraperitoneally to male Charles-River CD-1 mice. Hepatic metabolites were isolated by solvent extraction and chromatography on Sephadex LH-20 and identified by GC/MS. Eleven metabolites were identified fromn-hexyl-delta-8-THC and sixteen fromn-hexyl-delta-9-THC. The pattern of metabolites was… 

GC-MS Metabolite Profile and Identification of Unusual Homologous Cannabinoids in High Potency Cannabis sativa.

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Phytochemical investigation of the lipids extracted from seeds of Cannabis sativa by GC-MS showed 43 cannabinoids, 16 of which are new, and the mass spectrum of these homologues as trimethylsilyl (TMS) derivatives are presented and the fragmentation patterns are discussed.

Biotransformation of Tetrahydrocannabinol

TLDR
This review article assesses the current knowledge on the biotransformation of tetrahydrocannabinol and with particular focus on ∆9-THC.

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