Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: identification of CYP2A6 as a major catalyst.

@article{Hong1999MetabolismOM,
  title={Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: identification of CYP2A6 as a major catalyst.},
  author={Jungil Hong and Yan Yan Wang and Flordeliza Y. Bondoc and Maojung Lee and Chung S Yang and Wei Hu and Jishen Pan},
  journal={Toxicology and applied pharmacology},
  year={1999},
  volume={160 1},
  pages={43-8}
}
To reduce the production of carbon monoxide and other pollutants in motor vehicle exhaust, methyl tert-butyl ether (MTBE), ethyl tert-butyl ether (ETBE), and tert-amyl methyl ether (TAME) are added to gasoline as oxygenates for more complete combustion. Previously, we demonstrated that human liver is active in metabolizing MTBE to tert-butyl alcohol (TBA) and that cytochrome P450 (CYP) enzymes play a critical role in the metabolism of MTBE. The present study demonstrates that human liver is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Dermal, oral, and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers.

Toxicological sciences : an official journal of the Society of Toxicology • 2004
View 1 Excerpt
Highly Influenced

Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants.

J Han, X He, +3 authors Jun-yan Hong
Drug metabolism and disposition: the biological fate of chemicals • 2008
View 2 Excerpts

Similar Papers

Loading similar papers…