Metabolism of methocarbamol (robaxin) in the isolated perfused rat liver and identification of glucuronides.

@article{Thompson1975MetabolismOM,
  title={Metabolism of methocarbamol (robaxin) in the isolated perfused rat liver and identification of glucuronides.},
  author={R. M. Thompson and N. Gerber and R. Seibert},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1975},
  volume={5 3},
  pages={
          145-53
        }
}
1. Permethylation and g.l.c.-mass spectrometric analysis of bile from an isolated rat liver perfusion to which methocarmol was added showed seven components not present in control bile: methocarbamol, glucuronides of methocarbamol and desmethyl-methocarbamol, and four glucuronides of hydroxylated methocarbamol metabolites. 2. An interesting rearrangement of a methyl group has been found in the mass spectrum of 3-(2-methoxyphenyloxy)-1,2-dimethoxypropane, the permethylation product from… Expand
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A rapid method for the mass spectrometric identification of glucuronides and other polar drug metabolites in permethylated rat bile.
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A technique for rapidly screening drugs and other compounds for possible glucuronide formation has been developed andact glucuronides of hydroxydiphenylhydantoin, hydroxymephobarbital, chloramphenicol, 2-methyl-1,4-dihydroxynaphthalene (reduced menadione), and others have been detected. Expand
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Several types of studies were undertaken on dogs to clarify the metabolic fate of C 14 -metho-carbamol, and some of the metabolites of methocarbamol were not chloroform extractable from hydrolyzed and alkalinized urine. Expand
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A Series of barbiturates (I) has been permethylated with the methylsulfinylmethide carbanion and methyl iodide and the products (II to IV) separated, quantified and characterized by g.c.-m.s. TheExpand
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Abstract The amino acid sequence of oligopeptides can be determined from the mass spectra of their volatile derivatives. A general procedure for the N-acetylation and N,O,S-permethylation of unknownExpand