Metabolism of methocarbamol (robaxin) in the isolated perfused rat liver and identification of glucuronides.

  title={Metabolism of methocarbamol (robaxin) in the isolated perfused rat liver and identification of glucuronides.},
  author={R. M. Thompson and N. Gerber and R. Seibert},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={5 3},
1. Permethylation and g.l.c.-mass spectrometric analysis of bile from an isolated rat liver perfusion to which methocarmol was added showed seven components not present in control bile: methocarbamol, glucuronides of methocarbamol and desmethyl-methocarbamol, and four glucuronides of hydroxylated methocarbamol metabolites. 2. An interesting rearrangement of a methyl group has been found in the mass spectrum of 3-(2-methoxyphenyloxy)-1,2-dimethoxypropane, the permethylation product from… Expand
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