Metabolism of mercapturic acid-pathway metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by gastrointestinal bacteria.

@article{Larsen1983MetabolismOM,
  title={Metabolism of mercapturic acid-pathway metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by gastrointestinal bacteria.},
  author={Gerald L Larsen and Jerome E. Bakke},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1983},
  volume={13 2},
  pages={115-26}
}
1. Mercapturic acid pathway metabolites of propachlor, labelled with 14C, were incubated with pig caecal contents, small and large intestinal contents, and pure cultures of gastrointestinal bacteria. 2. The glutathione, cysteine, N-acetylcysteine, and the S-oxide of the N-acetylcysteine conjugates of propachlor (2-chloro-N-isopropylacetanilide) were each metabolized by mixed pig caecal micro-organisms to 2-mercapto-N-isopropylacetanilide. 3. The extent of formation of 2-mercapto-N… CONTINUE READING