Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.

@article{Kim2013MetabolismOM,
  title={Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.},
  author={Tae-Kang Kim and Konrad Kleszczyński and Zorica Janjetovic and Trevor Sweatman and Zongtao Lin and Wei Li and Russell J Reiter and T W Fischer and Andrzej T Slominski},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 7},
  pages={2742-55}
}
Indolic and kynuric pathways of skin melatonin metabolism were monitored by liquid chromatography mass spectrometry in human keratinocytes, melanocytes, dermal fibroblasts, and melanoma cells. Production of 6-hydroxymelatonin [6(OH)M], N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and 5-methoxytryptamine (5-MT) was detected in a cell type-dependent fashion. The major metabolites, 6(OH)M and AFMK, were produced in all cells. Thus, in immortalized epidermal (HaCaT) keratinocytes, 6(OH)M was… CONTINUE READING

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