Metabolism of isorhynchophylline in rats detected by LC-MS.

@article{Wang2010MetabolismOI,
  title={Metabolism of isorhynchophylline in rats detected by LC-MS.},
  author={Wei Wang and Chao-Mei Ma and Masao Hattori},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2010},
  volume={13 1},
  pages={
          27-37
        }
}
PURPOSE This paper investigates the metabolic fate of isorhynchophylline (ISOR) as a main bioactive oxindole alkaloid in the traditional Chinese medicine. METHODS After oral administration of ISOR to rats, plasma, bile, urine and feces were analyzed by LC-MS. Hydroxylation of ISOR and successive glucuronidation proceeded in vitro by incubation with rat liver microsomes. RESULTS ISOR was identified in plasma, 11-hydroxyisorhynchophylline 11-O--D-glucuronide (MI1) and 10… CONTINUE READING

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