Metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline in the male rat.

@article{Inamasu1989MetabolismO2,
  title={Metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline in the male rat.},
  author={Takeo Inamasu and Howard Jay Luks and M T Vavrek and John h. Weisburger},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1989},
  volume={27 6},
  pages={369-76}
}
The metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was studied in the male rat using the radiochemical labels 14C and 3H at positions 2 and 5 of the molecule, respectively. Adult male Fischer 344 rats were administered [2-14C]IQ or [5-3H]IQ by oral gavage at dose levels of 20 or 40 mg/kg body weight. Rats were also given [2-14C]IQ in the diet at a dose level of 300 ppm for 2 days and after administration of unlabelled IQ (300 ppm) in the diet for approximately 6.5 wk for an… CONTINUE READING

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