Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line, and observations on metabolite stability.

@article{Coutts1993MetabolismOI,
  title={Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line, and observations on metabolite stability.},
  author={R. T. Coutts and P. Su and G. Baker and M. Daneshtalab},
  journal={Journal of chromatography},
  year={1993},
  volume={615 2},
  pages={
          265-72
        }
}
  • R. T. Coutts, P. Su, +1 author M. Daneshtalab
  • Published 1993
  • Chemistry, Medicine
  • Journal of chromatography
  • A metabolism study of imipramine (IMI) has been conducted in vitro with commercially available human CYP2D6 isozyme expressed in a human AHH-1 TK +/- cell line. This enzyme system catalyzed the anticipated ring-oxidative biotransformation of IMI to 2-hydroxyimipramine (2-OH-IMI). In addition, however, the human CYP2D6 isozyme preparation was found to be unequivocally involved in the N-dealkylation of IMI to desmethylimipramine (DMI). 2-Hydroxydesipramine was also identified as a trace… CONTINUE READING
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