Metabolism of hexafluoropropene. Evidence for bioactivation by glutathione conjugate formation in the kidney.

@article{Koob1990MetabolismOH,
  title={Metabolism of hexafluoropropene. Evidence for bioactivation by glutathione conjugate formation in the kidney.},
  author={Manfred Koob and Wolfgang Dekant},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1990},
  volume={18 6},
  pages={911-6}
}
We investigated the metabolism of hexafluoropropene, a nephrotoxic fluoroalkene, in rat liver and kidney subcellular fractions and in rats in vivo. Incubation of hexafluoropropene (1 mM) with microsomes and cytosol in the presence of glutathione (GSH) yielded S-(1,2,3,3,3-pentafluoropropenyl)glutathione (PPFG) and S-(1,1,2,3,3,3-hexafluoropropyl)glutathione (HFPG) as identified by thermospray mass spectrometry and 1H-NMR. In liver microsomes, PFPG formation was predominant (240 nmol/min/mg… CONTINUE READING

Similar Papers

Loading similar papers…