Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.

@article{Sakai2004MetabolismOH,
  title={Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.},
  author={Hiromi Sakai and Hirohisa Horinouchi and Yoshiyasu Masada and Shinji Takeoka and Eiji Ikeda and Masuhiko Takaori and Koichi Kobayashi and Eishun Tsuchida},
  journal={Biomaterials},
  year={2004},
  volume={25 18},
  pages={
          4317-25
        }
}
Phospholipid vesicles encapsulating Hb (Hb-vesicles: HbV) have been developed for use as artificial O(2) carriers (250 nm phi). As one of the safety evaluations, we analyzed the influence of HbV on the organ functions by laboratory tests of plasma on a total of 29 analytes. The HbV suspension ([Hb]=10 g/dl) was intravenously infused into male Wistar rats (20 ml/kg; whole blood = 56 ml/kg). The blood was withdrawn at 8h, and 1, 2, 3, and 7 days after infusion, and the plasma was ultracentrifuged… CONTINUE READING
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