Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity.

@article{Bae2002MetabolismOG,
  title={Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity.},
  author={E. Bae and M. Choo and E. Park and Sun-Young Park and Hoyoung Shin and D. Kim},
  journal={Biological \& pharmaceutical bulletin},
  year={2002},
  volume={25 6},
  pages={
          743-7
        }
}
  • E. Bae, M. Choo, +3 authors D. Kim
  • Published 2002
  • Biology, Medicine
  • Biological & pharmaceutical bulletin
When ginsenoside R(c) was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside R(c) to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidobacterium sp. potently transformed ginsenoside R(c) to compound K. Bifidobacterium K-103 and Eubacterium A-44 transformed it to compound K via ginsenoside R(d) and Bacteroides HJ-15… Expand
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TLDR
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TLDR
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TLDR
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References

SHOWING 1-10 OF 17 REFERENCES
Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria.
TLDR
Ginsenoside Rb1 and Rb2 were anaerobically incubated with human intestinal microflora and several kinds of intestinal bacteria hydrolyzed these ginsenosides, causing them to be metabolized to 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (compound K) and 20(S) - protopanxadiol. Expand
Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities.
TLDR
Ginsenoside Rg3 and its metabolites exhibited the most potent cytotoxicity against tumor cell lines, 20(S)- and 20(R)-protopanaxadiols potently inhibited the growth of Helicobacter pylori, and 20 (S)-ginsenoside Rh2 inhibited H+/K+ ATPase of rat stomach. Expand
Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins.
TLDR
The results suggest that the metabolism of protopanaxadiol saponins to metabolites I-III in the intestines seems most partly due to intestinal P. oris isolates. Expand
Main ginseng saponin metabolites formed by intestinal bacteria.
Ginseng saponin metabolites produced by human intestinal bacteria and the urinary and blood compounds after oral administration of Ginseng extract and its saponins in human and specific pathogen-freeExpand
In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration.
TLDR
The present study demonstrated in vivo and in vitro antimetastatic activities of a major intestinal bacterial metabolite M1 formed from protopanaxadiol saponins of ginseng in comparison with its whole standardized extract and ginsenoside Rb1, Rb2, and Rc. Expand
Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration--measurement of compound K by enzyme immunoassay.
TLDR
Plasma C-K after the oral administration of C- K and G-Rb1 to rats was determined by the established EIA and appeared late and was retained for a long period of time in the plasma after the administration of G- Rb1, which itself is hardly absorbed. Expand
Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin.
TLDR
The results suggest that IH-901 is not cross-resistant to CDDP in this cell line and could be a candidate for the treatment of CDDP resistant pulmonary cancer. Expand
Drug Metabolism: Intestinal Bacterial Hydrolysis is Required for the Appearance of Compound K in Rat Plasma after Oral Administration of Ginsenoside Rb1 from Panax ginseng
TLDR
Ginsenoside Rb1 from Panax ginseng root is transformed into compound K via ginsenosides Rd and F2 by intestinal bacterial flora by Eubacterium sp. Expand
Chemical Studies on the Oriental Plant Drugs. XXVIII. Saponins and Sapogenins of Ginseng : Stereochemistry of the Sapogenin of Ginsenosides-Rb1, -Rb2 and -Rc
The sapogenin of Ginseng saponins, ginsenosides-Rb1, -Rb2 and -Rc, was once reported to be protopanaxadiol (III). But it was found recently that dammarane type triperpenes with hydroxyl or methoxylExpand
Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats.
TLDR
It appears that hydrolysis by beta-glucosidase, which is present in the rat large intestine, is distinct from that by crude hesperidinase. Expand
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