Metabolism of exogenous sex steroids and effect on brain functions with a focus on tibolone

@article{Verheul2006MetabolismOE,
  title={Metabolism of exogenous sex steroids and effect on brain functions with a focus on tibolone},
  author={H. Verheul and H. Kloosterboer},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2006},
  volume={102},
  pages={195-204}
}
Around the menopause, changes in ovarian secretion of steroids result in changes in brain function: hot flushes and sweating later followed by changes in mood, libido and cognition. The relationship between sex steroids and brain functions are reviewed, with focus on hormonal treatments, in particular tibolone, on the postmenopausal brain and on associations between tissue levels and brain functions. Data on steroid levels in human brain are limited. Exogenous oestrogens alone or combined with… Expand
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TLDR
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Effect of tibolone on dendritic spine density in the rat hippocampus.
INTRODUCTION Oestrogen deficiency produces oxidative stress (OS) and changes in hippocampal neurons and also reduces the density of dendritic spines (DS). These alterations affect the plasticExpand
Effect of tibolone on dendritic spine density in the rat hippocampus
TLDR
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