Metabolism of ether phospholipids and analogs in neoplastic cells

@article{Fleer2006MetabolismOE,
  title={Metabolism of ether phospholipids and analogs in neoplastic cells},
  author={E. A. Fleer and C. Unger and D. Kim and H. Eibl},
  journal={Lipids},
  year={2006},
  volume={22},
  pages={856-861}
}
The ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (OM-GPC) is known to be a potent inhibitor of cell growth. Metabolic studies in both Raji and L1210 leukemic cells on OM-GPC,3H-labeled in the methyl groups of the choline moiety, showed a (diacyl)-phosphatidylcholine as the only labeled metabolite. Since the formation of radiolabeled (diacyl)-phosphatidylcholine showed a direct correlation with cell death, we tested other lipid analogs. One of these compounds… Expand
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