Metabolism of ethanol to acetaldehyde and increased susceptibility to oxidative stress could play a role in the ovarian tissue cell injury promoted by alcohol drinking.

@article{Faut2009MetabolismOE,
  title={Metabolism of ethanol to acetaldehyde and increased susceptibility to oxidative stress could play a role in the ovarian tissue cell injury promoted by alcohol drinking.},
  author={M{\'o}nica Faut and Carmen Rodr{\'i}guez de Castro and Florencia Matilde Bietto and Jos{\'e} Alberto de Castro and Gerardo Castro},
  journal={Toxicology and industrial health},
  year={2009},
  volume={25 8},
  pages={
          525-38
        }
}
It is known that drinking alcohol can lead to reproductive problems in women. In this study, we analyzed the possibility that part of those effects were mediated through alterations of ovarian function related to ethanol oxidation to acetaldehyde occurring in situ. Biotransformation in the rat ovary cytosolic fraction was partially inhibited by allopurinol, suggesting the participation of xanthine oxidoreductase in the process. Microsomal pathway was of enzymatic nature, requiring nicotinamide… CONTINUE READING
BETA