Metabolism of ethanol in rat gastric cells and its inhibition by cimetidine.

BACKGROUND/AIMS Several studies have shown that the stomach has sufficient alcohol dehydrogenase activity to metabolize a significant amount of alcohol and that cimetidine depresses this alcohol dehydrogenase activity. However, both gastric metabolism of ethanol and its inhibition by cimetidine remain controversial. Given the difficulty in assessing gastric… CONTINUE READING