Metabolism of enterostatin in rat intestine, brain membranes, and serum: Differential involvement of proline-specific peptidases

@article{Bouras1995MetabolismOE,
  title={Metabolism of enterostatin in rat intestine, brain membranes, and serum: Differential involvement of proline-specific peptidases},
  author={Mohammed Bouras and Jean François Huneau and Catherine Luengo and Charlotte Erlanson-Albertsson and Daniel Tom{\'e}},
  journal={Peptides},
  year={1995},
  volume={16},
  pages={399-405}
}
The degradation of enterostatin (VPDPR), a potent inhibitor of food intake, by intestinal brush-border membranes, brain membranes, and rat serum has been investigated in the presence of specific inhibitors. Hydrolysis by intestinal membranes was found to be 10 and 100 times faster than in serum and brain membranes, respectively. Enterostatin hydrolysis by intestinal and brain membranes involves the removal of C-terminal arginine by carboxypeptidase P, leading to the production of des-Arg… CONTINUE READING