Metabolism of endocannabinoids and related N‐acylethanolamines: Canonical and alternative pathways

  title={Metabolism of endocannabinoids and related N‐acylethanolamines: Canonical and alternative pathways},
  author={Natsuo Ueda and Kazuhito Tsuboi and Toru Uyama},
  journal={The FEBS Journal},
Endocannabinoids are endogenous ligands of the cannabinoid receptors CB1 and CB2. Two arachidonic acid derivatives, arachidonoylethanolamide (anandamide) and 2‐arachidonoylglycerol, are considered to be physiologically important endocannabinoids. In the known metabolic pathway in mammals, anandamide and other bioactive N‐acylethanolamines, such as palmitoylethanolamide and oleoylethanolamide, are biosynthesized from glycerophospholipids by a combination of Ca2+‐dependent N‐acyltransferase and N… 
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