Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450.

Abstract

Epoxidation and hydroxylation of arachidonic acid (AA) are both catalyzed by cytochromes P450s (CYPs). The oxidized metabolites are known to be involved in the regulation of vascular tone and renal function. By using a panel of 15 human recombinant CYPs, this study demonstrates that other polyunsaturated long-chain fatty acids (PUFA-LC), especially the… (More)
DOI: 10.1016/j.abb.2008.01.002

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