Metabolism of dietary genotoxins by the human colonic microflora; the fecapentaenes and heterocyclic amines.


The microflora of the human colon is a complex ecosystem of anaerobic bacteria which have the capability of enzymatically transforming a variety of dietary (or biliary) compounds to genotoxic metabolites. In the past, most investigators studying the interplay between diet and colonic flora and its role in the etiology of cancers focused on the reductive and… (More)


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