Metabolism of debrisoquine sulfate. Identification of some urinary metabolites in rat and man.

@article{Allen1975MetabolismOD,
  title={Metabolism of debrisoquine sulfate. Identification of some urinary metabolites in rat and man.},
  author={J. Garrott Allen and P. B. East and Robert J. Francis and J L Haigh},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1975},
  volume={3 5},
  pages={332-7}
}
A high proportion of an oral dose of 14C-debrisoquine sulfate is excreted in the urine by rat and man. The urinary radioactivity consists of a mixture of unchanged drug and polar, water-soluble metabolites which cannot be extracted into organic solvents. Treatment of methanolic extracts of the freeze dried urine with acetylacetone incorporates the amidino group of debrisoquine and these metabolites into a 4,6-dimethylpyrimidine ring, and yields derivatives which can be readily extracted from… CONTINUE READING

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