Metabolism of crystals within the joint.
@article{Oliviero2012MetabolismOC, title={Metabolism of crystals within the joint.}, author={Francesca Oliviero and A. Scanu and Leonardo Punzi}, journal={Reumatismo}, year={2012}, volume={63 4}, pages={ 221-9 } }
Monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals deposit in joints and surrounding tissues causing acute inflammation and chronic cartilage damage. A number of endogenous substances and physicochemical conditions affect their precipitation, growth and even dissolution, regulating their metabolism and inflammatory activity. We review how MSU and calcium crystals form within the joints and the various factor which regulate their formation.
16 Citations
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- MedicineMedical ultrasonography
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This review will present the main US findings in gout, the utility of the method in diagnosis and treatment response, and comparison with other imaging techniques in terms of sensibility and specificity of the methods for this pathological situation.
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Different proteins and factors within connective tissues may promote MSU crystalsization and may be important for determining the sites at which MSU crystallization occurs in the presence of elevated urate concentrations.
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NEUTROPHIL EXTRACELLULAR TRAPS RELEASE IN GOUT AND PSEUDOGOUT DEPENDS ON THE NUMBER OF CRYSTALS REGARDLESS OF LEUKOCYTE COUNT.
- MedicineRheumatology
- 2021
Findings suggest that a role of NETs in crystal-induced arthritis is to "trap extracellular particles", including microcrystals, may be the basis of tophi and CPPD deposition and may have implications for disease evolution, rather than for spontaneous resolution of the acute attack.
Urate crystal degradation for treatment of gout: a nanoparticulate combination therapy approach
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The combination treatment therapy resulted in effective treatment of gout due to degradation of crystals and anti-inflammatory response, and the developed nanoparticles formulations displayed zero order and Higuchi release kinetics with non-Fickian diffusion.
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