Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis.

@article{Uetrecht1992MetabolismOC,
  title={Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis.},
  author={Jack Uetrecht},
  journal={Drug safety},
  year={1992},
  volume={7 Suppl 1},
  pages={
          51-6
        }
}
Many types of adverse drug reactions appear to involve reactive metabolites which, by their very nature, usually have short biological half-lives. Therefore, reactive metabolites formed by neutrophils, or neutrophil precursors in the bone marrow, would seem more likely to be responsible for drug-induced agranulocytosis than metabolites formed in the liver. We have found that several drugs associated with a relatively high incidence of drug-induced agranulocytosis are metabolised by activated… CONTINUE READING

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