Metabolism of cisplatin in the organs of Rattus norvegicus: role of Glutathione S-transferase P1

@article{Nagar2014MetabolismOC,
  title={Metabolism of cisplatin in the organs of Rattus norvegicus: role of Glutathione S-transferase P1},
  author={Ritika Nagar and Amir Riyaz Khan and Anuj Poonia and Pankaj Mishra and Simendra Singh},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2014},
  volume={40},
  pages={45-51}
}
Glutathione S-transferases (GSTs) play an important role in the biotransformation of endogenous compounds and xenobiotics as well as in the metabolic inactivation of pharmacologically active substances, including anticancer drugs. Using cisplatin as the prototype drug, we investigated if any correlation exists between GSH levels, GSTs/GSTP1 activity and the… CONTINUE READING