Metabolism of chloronitrobenzenes by isolated rat hepatocytes.

  title={Metabolism of chloronitrobenzenes by isolated rat hepatocytes.},
  author={Donald E. Rickert and Stephanie Held},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={18 1},
The metabolism of radiolabeled monochloronitrobenzene isomers was compared in isolated hepatocytes and hepatic subcellular fractions from male Fischer-344 rats. 2-Chloronitrobenezene was converted by isolated hepatocytes to 2-chloroaniline, 2-chloroaniline-N-glucuronide, and S-(2-nitrophenyl)glutathione in approximately equal quantities (13-19% of the added substrate in 90 min). The major metabolite formed from 3-chloronitrobenzene by isolated hepatocytes was 3-chloroaniline (31% of the added… CONTINUE READING

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