Metabolism of ceramide-containing endocytotic vesicles in human diploid fibroblasts.

Abstract

Two isoenzymes of ceramidase, including lysosomal acid ceramidase and nonlysosomal alkaline ceramidase, catalyze the degradation of ceramide in cultured human skin fibroblasts. A genetically determined disorder of sphingolipid metabolism (Farber's-disease) is characterized by the deficiency of acid ceramidase and by the pathological accumulation of ceramide… (More)

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