Metabolism of catecholamines--identification and quantification of 3-methoxy-4-hydroxyphenylglycol glucuronide in human urine.

@article{Shimizu1969MetabolismOC,
  title={Metabolism of catecholamines--identification and quantification of 3-methoxy-4-hydroxyphenylglycol glucuronide in human urine.},
  author={H. Shimizu and E. Labrosse},
  journal={Biochemical pharmacology},
  year={1969},
  volume={18 7},
  pages={
          1643-54
        }
}
Abstract The glucuronic acid conjugate of 3-methoxy-4-hydroxyphenylglycol(MHPG) has been isolated from human urine and its identification is described. This compound has been found to be a metabolite of dl -MHPG- 3 h and of DL-norepinephrine- 14 C. The quantities of MHPG, MHPG sulfate and MHPG glucuronide which are present in normal human urine, and in the urine of patients with neuroblastoma, ganglioneuroma and pheochromocytoma, indicate that the glucuronic acid conjugate is a major metabolite… Expand
The evaluation of 4-hydroxy-3-methoxyphenylglycol sulfate as a possible marker of central norepinephrine turnover. Studies in healthy volunteers and depressed patients.
TLDR
Results of two experiments indicate that alteration of peripheral norepinephrine turnover changes the urinary excretion of MHPG glucuronide only and not that of sulfate, thus providing strong, albeit indirect, evidence for a primarily central origin ofMHPG sulfate. Expand
Urinary conjugates of 4-hydroxy-3-methoxyphenylethylene glycol do not provide an index of brain amine turnover in man.
TLDR
It is concluded from data that both HMPG sulphate and HMPG glucuronide have a substantial peripheral origin and that measurements of their urinary excretion cannot be used as an index of brain catecholamine turnover. Expand
Sulfate and glucuronide conjugates of 3-methoxy-4-hydroxyphenylglycol (MHPG) in urine of depressed patients: Central and peripheral influences
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Urinary MHPG provides in depressed patients an index of the psychobiological state, involving central and peripheral components, and any factor acting on either of both components is able to modify MHGP excretion. Expand
Chiral analysis of 3-methoxy-4-hydroxyphenylglycol in human urine.
TLDR
The urinary MHPG was found to be D-(-)-MHPG, and the absolute configuration of enantioseparated MHPGs were assigned to each optical rotation, judging from the chemical data and the metabolic pathway of the urinary D-MHPG. Expand
Determination of conjugated monoamine metabolites in brain tissue
TLDR
Levels of free and conjugated monoamine metabolites were analysed in brain tissue of rat and man and the major dopamine metabolite found in this human brain was HVA. Expand
Free and conjugated 3-methoxy-4-hydroxyphenylglycol in human urine: Peripheral origin of glucuronide
TLDR
The total amounts of free, sulfate, and glucuronide MHPG found in urine originate from endogenous body pools with no interference of dietary components and the sympathetic nervous system seems to be the main source of glucuronides. Expand
Urinary excretion of 4-hydroxy-3-methoxyphenylglycol and 4-hydroxy-3-methoxyphenylethanol in man and rat.
TLDR
Since the HMPE and HMPG were also found in the urine of rats fed on an artificial casein diet it is suggested that they are produced endogenously. Expand
Stereoselective excretion of (3-methoxy-4-sulphooxyphenyl)ethylene glycol (MHPG sulphate) in the dog
TLDR
3-Methoxy-4-hydroxyphenylethylene glycol labelled with six deuterium atoms was infused into two female greyhound dogs and it was shown that the major forms of MHPG and [2H6]MHPG in the plasma and urine of the greyhounds were the sulphate conjugates. Expand
Mass fragmentographic determination of 4-hydroxy-3-methoxyphenylglycol (HMPG) in urine, cerebrospinal fluid, plasma and tissues using a deuterium-labelled internal standard.
TLDR
HMPG-D3 was used as the internal standard in the mass fragmentographic determination of free and conjugated HMPG in human urine, cerebrospinal fluid and plasma and in rat urine, liver and brain. Expand
Monoamine metabolites and related compounds in human amniotic fluid: assay by gas chromatography and gas chromatography-mass spectrometry.
TLDR
Assay of 4-hydroxy-3-methoxyphenylglycol in amniotic fluid is likely to be of diagnostic importance in the prenatal diagnosis of congenital neuroblastoma. Expand
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