Metabolism of carbidopa to alpha-methyldopamine and alpha-methylnorepinephrine in rats.

@article{Shelton1985MetabolismOC,
  title={Metabolism of carbidopa to alpha-methyldopamine and alpha-methylnorepinephrine in rats.},
  author={Richard Charles Shelton and Farouk Karoum and Lisen Chuang and Richard Jed Wyatt},
  journal={Biochemical pharmacology},
  year={1985},
  volume={34 20},
  pages={3623-6}
}
Recent observations on the central and peripheral actions of carbidopa (CD) combined with our own results with the compound led us to examine its metabolism and effects on brain catecholamines in rats. CD was found to undergo a two-stage N-deamination process in vivo giving rise to alpha-methyldopa (AMD) and alpha-methyldopamine respectively. Further, beta… CONTINUE READING