Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.

@article{Reilly2003MetabolismOC,
  title={Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.},
  author={Christopher A. Reilly and William J Ehlhardt and David A. Jackson and Palaniappan Kulanthaivel and Abdul E Mutlib and Robert J Espina and David E. Moody and Dennis J. Crouch and Garold S. Yost},
  journal={Chemical research in toxicology},
  year={2003},
  volume={16 3},
  pages={336-49}
}
Capsaicin is a common dietary constituent and a popular homeopathic treatment for chronic pain. Exposure to capsaicin has been shown to cause various dose-dependent acute physiological responses including the sensation of burning and pain, respiratory depression, and death. In this study, the P450-dependent metabolism of capsaicin by recombinant P450 enzymes and hepatic and lung microsomes from various species, including humans, was determined. A combination of LC/MS, LC/MS/MS, and LC/NMR was… CONTINUE READING
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