Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans.

@article{Pritchett2002MetabolismOB,
  title={Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans.},
  author={J J Pritchett and Robert K. Kuester and I. Glenn Sipes},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 11},
  pages={
          1180-5
        }
}
Studies have shown that in the rat, bisphenol A (BPA) is metabolized and eliminated primarily as a monoglucuronide, a metabolite without estrogenic activity. The purpose of this study was to determine the extent of monoglucuronide formation in monolayers of hepatocytes from rats, mice, and humans. Noncytotoxic concentrations of BPA (10, 20, and 35 microM; 1.0 microCi), as assessed by lactate dehydrogenase leakage, were incubated with isolated hepatocytes for 0-6 h. Media were collected and… 

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