Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.

@article{Beall1994MetabolismOB,
  title={Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.},
  author={Howard D. Beall and R. Timothy Mulcahy and David Siegel and Robert D. Traver and Neil W. Gibson and David D. Ross},
  journal={Cancer research},
  year={1994},
  volume={54 12},
  pages={3196-201}
}
The metabolisms of two standard electron acceptors and a series of bioreductive antitumor compounds by purified rat and human DT-diaphorases (DTD) were compared. DTD was purified from rat liver cytosol and from Escherichia coli in which rat liver or human lung tumor DTD complementary DNA was expressed. Km and kcat values for menadione and 2,6-dichlorophenolindophenol reduction were similar for the three enzyme preparations except that rat E. coli DTD had 2-3-fold higher kcat values for both… CONTINUE READING

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A CS 1954 analog that is highly cytotoxic in human tumor cell lines

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