Metabolism of benzo(a)pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives.

@article{Burke1977MetabolismOB,
  title={Metabolism of benzo(a)pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives.},
  author={Murray D. Burke and H V Vadi and Bengt Jernstr{\"o}m and Sten Orrenius},
  journal={The Journal of biological chemistry},
  year={1977},
  volume={252 18},
  pages={6424-31}
}
The metabolism of [Wlbenzo(a)pyrene with isolated hepatocytes from 3-methylcholanthrene-treated rats was examined with the aid of high pressure liquid chromatography. Covalent binding of [SHlbenzo(a)pyrene metabolites to the intracellular DNA was investigated. The effects of (Ynaphthoflavone, salicylamide, trichloropropene oxide, and diethylmaleate… CONTINUE READING