Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis.

@article{Voorhis1993MetabolismOA,
  title={Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis.},
  author={Bradley J. Van Voorhis and Michael Stephen Dunn and John R Falck and R. K. Bhatt and M Vanrollins and Gary D. Snyder},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={76 6},
  pages={1555-9}
}
Epoxyeicosatrienoic acids (EETs), cytochrome P-450 metabolites of arachidonic acid, have attracted attention because of their effects on stimulus-response coupling in endocrine, renal, and vascular cells. To investigate a possible role for EETs in ovarian physiology, we conducted a series of experiments using human luteinized granulosa cells. Granulosa cell microsomes produce EETs, which are identified by their comigration with known standards using reverse phase high pressure liquid… CONTINUE READING