Metabolism of antiarrhythmics.

  title={Metabolism of antiarrhythmics.},
  author={Huy Riem Ha and Ferenc Follath},
  journal={Current drug metabolism},
  volume={5 6},
Antiarrhythmics are a group of drugs that manage the irregular electrical activity of the heart. Their use in the clinic is made difficult by their narrow therapeutic index. The disposition of antiarrhythmics is dependent on many factors, such as administration route, stereoselectivity in the first-pass effect, inhibition of enzymes, polymorphisms, etc. Consequently, the pharmacological activity of drugs may be interindividually variable. Experiments using organ homogenates or hepatic microsome… CONTINUE READING