Metabolism of anethole. I. Pathways of metabolism in the rat and mouse.

@article{Sangster1984MetabolismOA,
  title={Metabolism of anethole. I. Pathways of metabolism in the rat and mouse.},
  author={S. A. Sangster and John Caldwell and R. Smith and Peter B. Farmer},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1984},
  volume={22 9},
  pages={
          695-706
        }
}
  • S. A. Sangster, J. Caldwell, P. Farmer
  • Published 1 September 1984
  • Chemistry, Biology
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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28 Citations
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28 Citations

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Citation Type

The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the…
Influence of dose size on the disposition of trans-[methoxy-14C]anethole in human volunteers.
  • J. Caldwell, J. D. Sutton
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1988
The metabolic disposition of (meth~xy-~~Cl-labelled trans-anethole, estragole and ppropxlanisole in human volunteers
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the…
Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro
TLDR
Among numerous urinary metabolites associated with hydrolysis of the ester, two potential reproductive and developmental toxicants, 2- methylhexanol and 2-ethylhexanoic acid were produced by metabolism of EHMC.
Studies on benzyl acetate. II. Use of specific metabolic inhibitors to define the pathway leading to the formation of benzylmercapturic acid in the rat.
  • M. Chidgey, J. F. Kennedy, J. Caldwell
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1986
New studies on trans-anethole oxide and trans-asarone oxide.
TLDR
Synthetic trans-Anethole oxide prepared from trans-anethole and dimethyldioxirane is not only mutagenic for Salmonella tester strains but is also carcinogenic in the induction of hepatomas in B6C3F1 mice and skin papillomas in CD-1 mice.
Lack of influence of modulators of epoxide metabolism on the genotoxicity of trans-anethole in freshly isolated rat hepatocytes assessed with the unscheduled DNA synthesis assay.
  • A. D. Marshall, J. Caldwell
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1996
Stereochemical aspects of the hydration of trans-anethole epoxide in the rat.
TLDR
The stereochemical course of the metabolism of trans-anethole by rat liver microsomes and cytosol is discussed and the stereochemistry of the diols produced was determined by HPLC as their dicamphanyl esters.
The FEMA GRAS assessment of trans-anethole used as a flavouring substance. Flavour and Extract Manufacturer's Association.
  • P. Newberne, R. Smith, R. A. Ford
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1999
Naturally occurring oestrogens in foods--a review.
TLDR
Indications are given of the wide range of common food plants which have been reported to possess oestrogenic (uterotropic) activity, although it is emphasized that in general further work is necessary to substantiate these claims and to confirm the identities of the biologically active principles which have in some cases been proposed.
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References

SHOWING 1-10 OF 21 REFERENCES
The metabolism of p-propylanisole in the rat and mouse and its variation with dose.
Metabolism of styrene oxide in the rat and guinea pig.
TLDR
The hitherto unobserved dihydrodiol formed via an arene oxide was found as a minor metabolite for both styrene and styrene oxide.
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
TLDR
Twenty-three naturally occurring and synthetic alkenylbenzene derivatives structurally related to the hepatocarcinogen safrole were assayed for their hepatocARCinogenicity in mice to identify benign skin tumors that could be promoted with croton oil.
The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat.
1. The chief sulphur-containing metabolite of styrene and sytrene oxide in the rabbit and rat is chromatographically identical with N-acetyl-S-(beta-hydroxyphenethyl)-l-cysteine and this compound is…
Metabolism of naturally occurring propenylbenzene derivatives
Studies on metabolism and toxicity of styrene: III. The effect of metabolic inactivation by rat-liver S9 on the mutagenicity of phenyloxirane toward Salmonella typhimurium.
Stereoselective oxidation of styrene to styrene oxide in rats as measured by mercapturic acid excretion.
TLDR
There is a stereoselective oxidation of styrene to styrene oxide, with a preference for the R-isomer, according to the observed ratio of the diastereoisomers for both hydroxymercapturic acids.
3-Hydroxy- and 3-keto-3-phenylpropionic acids: novel metabolites of benzoic acid in horse urine.
Cysteine conjugate β-lyase and the thiomethyl shunt
TLDR
It is demonstrated that increased microsomalassociated transferases have complete immunological identity with cytosolic liver transferases, and it remains an open question regarding the natural substrates of glutathione S-transferases and their additional biological functions in vivo.
Thiol S-methyltransferase from rat liver.
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