Metabolism of anethole. I. Pathways of metabolism in the rat and mouse.

@article{Sangster1984MetabolismOA,
  title={Metabolism of anethole. I. Pathways of metabolism in the rat and mouse.},
  author={S. A. Sangster and John Caldwell and R. Smith and Peter B. Farmer},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1984},
  volume={22 9},
  pages={
          695-706
        }
}
  • S. A. Sangster, J. Caldwell, P. Farmer
  • Published 1 September 1984
  • Chemistry, Biology
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the
Influence of dose size on the disposition of trans-[methoxy-14C]anethole in human volunteers.
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  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1988
The metabolic disposition of (meth~xy-~~Cl-labelled trans-anethole, estragole and ppropxlanisole in human volunteers
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the
Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro
TLDR
Among numerous urinary metabolites associated with hydrolysis of the ester, two potential reproductive and developmental toxicants, 2- methylhexanol and 2-ethylhexanoic acid were produced by metabolism of EHMC.
Studies on benzyl acetate. II. Use of specific metabolic inhibitors to define the pathway leading to the formation of benzylmercapturic acid in the rat.
  • M. Chidgey, J. F. Kennedy, J. Caldwell
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1986
New studies on trans-anethole oxide and trans-asarone oxide.
TLDR
Synthetic trans-Anethole oxide prepared from trans-anethole and dimethyldioxirane is not only mutagenic for Salmonella tester strains but is also carcinogenic in the induction of hepatomas in B6C3F1 mice and skin papillomas in CD-1 mice.
Lack of influence of modulators of epoxide metabolism on the genotoxicity of trans-anethole in freshly isolated rat hepatocytes assessed with the unscheduled DNA synthesis assay.
  • A. D. Marshall, J. Caldwell
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1996
Stereochemical aspects of the hydration of trans-anethole epoxide in the rat.
TLDR
The stereochemical course of the metabolism of trans-anethole by rat liver microsomes and cytosol is discussed and the stereochemistry of the diols produced was determined by HPLC as their dicamphanyl esters.
The FEMA GRAS assessment of trans-anethole used as a flavouring substance. Flavour and Extract Manufacturer's Association.
  • P. Newberne, R. Smith, R. A. Ford
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1999
Naturally occurring oestrogens in foods--a review.
TLDR
Indications are given of the wide range of common food plants which have been reported to possess oestrogenic (uterotropic) activity, although it is emphasized that in general further work is necessary to substantiate these claims and to confirm the identities of the biologically active principles which have in some cases been proposed.
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