Metabolism of aminopyrine and derivatives in man: in vivo study of monomorphic and polymorphic metabolic pathways.

@article{Agndez1995MetabolismOA,
  title={Metabolism of aminopyrine and derivatives in man: in vivo study of monomorphic and polymorphic metabolic pathways.},
  author={Jos{\'e} A. G. Ag{\'u}ndez and Carmen Mart{\'i}nez and Julio Cesar Munoz Benitez},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1995},
  volume={25 4},
  pages={417-27}
}
1. The main metabolic pathways involved in the biodisposition of aminopyrine have been monitored in vivo in 60 healthy volunteers by measuring the amount of parent drug and metabolites recovered in the urine 24 h after oral administration of 250 mg aminopyrine. 2. The amount of metabolites in the 24-h urine was (mean +/- SD of 60 individuals): unchanged… CONTINUE READING