Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon.

@article{Autrup1979MetabolismOA,
  title={Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon.},
  author={Herman Autrup and John M Essigmann and Robert G. Croy and Benjamin F. Trump and Gerald N. Wogan and Curtis C. Harris},
  journal={Cancer research},
  year={1979},
  volume={39 3},
  pages={694-8}
}
Aflatoxin B1 and benzo(a)pyrene were activated by both cultured human bronchus and human colon as measured by binding to cellular DNA and protein. The binding of aflatoxin B1 to DNA was dose dependent, and the level of binding was higher in cultured human bronchus than it was in the colon. When compared to aflatoxin B1, the binding level of benzo(a)pyrene to both bronchial and colonic DNA was generally higher. The major adducts formed in both tissues by the interaction of aflatoxin B1 and DNA… CONTINUE READING
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