Metabolism of adenosine through adenosine kinase inhibits gluconeogenesis in isolated rat hepatocytes.

Abstract

In isolated hepatocytes from fasted rats, 0.5 mM adenosine inhibited gluconeogenesis from glutamine, lactate and pyruvate. This inhibition was due to adenosine conversion through adenosine kinase. An increase in ketone body release was only observed in the presence of lactate or pyruvate, and the two phenomena (i.e. inhibition of gluconeogenesis and… (More)

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Cite this paper

@article{Lavoinne1990MetabolismOA, title={Metabolism of adenosine through adenosine kinase inhibits gluconeogenesis in isolated rat hepatocytes.}, author={Alain M Lavoinne and Sophie Claeyssens and Arlette Chedeville}, journal={European journal of biochemistry}, year={1990}, volume={187 2}, pages={403-7} }