Metabolism of adenosine analogues by Schistosoma mansoni and the effect of nucleoside transport inhibitors.

@article{elKouni1987MetabolismOA,
  title={Metabolism of adenosine analogues by Schistosoma mansoni and the effect of nucleoside transport inhibitors.},
  author={Mahmoud H. el Kouni and Sungman Cha},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 7},
  pages={
          1099-106
        }
}
Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni.
Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii
TLDR
It appears that the unique characteristics of purine metabolism in T. gondii render certain 6-substituted 9-β-d-ribofuranosylpurines promising antitoxoplasmic drugs.
Pyrimidine salvage pathways in adult Schistosoma mansoni.
Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues.
TLDR
The results reveal that the Schistosoma mansoni AK can be sterically occluded in the absence of ATP, and contribute to the body of knowledge concerning the enzymes of the purine salvage pathway in this important human parasite.
Uptake of Nitrobenzylthioinosine and Purine β-l-Nucleosides by Intracellular Toxoplasma gondii
TLDR
Infection with T. gondii confers the properties of the parasite's purine nucleoside transport on the parasitized host cells and enables the infected cells to transport purines that were not transported by uninfected cells, which may aid in the identification of new promising antitoxoplasmic drugs.
Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis
TLDR
Host toxicity of the dose regimen of tubercidin plus nitrobenzylthioinosine 5'-monophosphate (NBMPR-P) used in combination therapy of schistosomiasis was examined in vivo in mice and in vitro with human bone marrow progenitor cells, showing no evidence for injury to the liver, kidney, spleen, pancreas, mesentery, or peritoneal mesothelium.
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