Metabolism of activated T lymphocytes.

@article{Maciolek2014MetabolismOA,
  title={Metabolism of activated T lymphocytes.},
  author={Jason A Maciolek and Jonathan Alexander Pasternak and Heather L Wilson},
  journal={Current opinion in immunology},
  year={2014},
  volume={27},
  pages={60-74}
}
Activated T cells undergo metabolic reprogramming which promotes glycolytic flux and lactate production as well as elevated production of lipids, proteins, nucleic acids and other carbohydrates (i.e. induction of biomass) even in the presence of oxygen. Activated T cells show induced expression of, among other things, Glucose Transporter 1 and several glycolytic enzymes, including ADP-Dependent Glucokinase and the low affinity isoform Pyruvate Kinase-M2 (which promote glycolytic flux), as well… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 128 references

Principles of Biochemistry, edn 6. Edited by Schultz L

  • DL Nelson, MC Michael
  • New York: WH Freeman and Company;
  • 2013
Highly Influential
13 Excerpts

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

  • R Wang, P Dillon Christopher, +7 authors J Munger
  • Immunity
  • 2011
Highly Influential
10 Excerpts

Gülow K: T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation

  • M Kamiński Marcin, W Sauer Sven, +6 authors H Krammer Peter
  • Cell Rep 2012,
  • 1315
Highly Influential
7 Excerpts

Activation of the hexosamine pathway leads to deterioration of pancreatic betacell function through Current Opinion in

  • H Kaneto, G Xu, +4 authors GC Weir
  • Immunology
  • 2014

Similar Papers

Loading similar papers…