Metabolism of activated T lymphocytes.

  title={Metabolism of activated T lymphocytes.},
  author={Jason A Maciolek and Jonathan Alexander Pasternak and Heather L Wilson},
  journal={Current opinion in immunology},
Activated T cells undergo metabolic reprogramming which promotes glycolytic flux and lactate production as well as elevated production of lipids, proteins, nucleic acids and other carbohydrates (i.e. induction of biomass) even in the presence of oxygen. Activated T cells show induced expression of, among other things, Glucose Transporter 1 and several glycolytic enzymes, including ADP-Dependent Glucokinase and the low affinity isoform Pyruvate Kinase-M2 (which promote glycolytic flux), as well… CONTINUE READING
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