Metabolism of a thromboxane A2 antagonist in isolated rat hepatocytes.

Metabolism of a thromboxane A2 antagonist (+/-)-5-(Z)-7-(3-endo-phenylsulphonylaminobicyclo[2.2.1]hept-2- exoyl)- heptenoic acid (S-145) in isolated rat hepatocytes was examined by high-performance liquid chromatography and gas chromatography/mass spectrometry. As the hydrophobic metabolites, bis-nor S-145, tetra-nor S-145 and bis-nordihydro S-145 were… CONTINUE READING