Metabolism of a novel hypnotic, N3-phenacyluridine, and hypnotic and sedative activities of its enantiomer metabolites in mouse

@article{Kimura2000MetabolismOA,
  title={Metabolism of a novel hypnotic, N3-phenacyluridine, and hypnotic and sedative activities of its enantiomer metabolites in mouse},
  author={T. Kimura and M. Miki and K. Watanabe and S. Kondo and I. Ho and I. Yamamoto},
  journal={Xenobiotica},
  year={2000},
  volume={30},
  pages={643 - 653}
}
  • T. Kimura, M. Miki, +3 authors I. Yamamoto
  • Published 2000
  • Chemistry, Medicine
  • Xenobiotica
  • 1. The metabolism of N3-phenacyluridine (3-phenacyl-1- beta-D-ribofuranosyluracil), a potent hypnotic nucleoside derivative, was studied in mouse. 2. Of the radioactivity, 65% was excreted in urine within 48 h after intraperitoneal (i.p.) administration of [3H] N3-phenacyluridine. The urinary metabolites N3-phenacyluracil and N3-alpha-hydroxy-beta-phenethyluridine were extracted, isolated and analyzed by mass spectrometry. 3. Racemates of N3-alpha-hydroxy-beta-phenethyluridine were synthesized… CONTINUE READING
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