Metabolism of a bisphosphonate ester (PNU-91638) in rat.

@article{Slatter1997MetabolismOA,
  title={Metabolism of a bisphosphonate ester (PNU-91638) in rat.},
  author={John Gregory Slatter and Kenneth L. Feenstra and M J Hauer and Phillip E. Sanders and James J. Vrbanac and Graham Vaughan Scott and William Speed},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1997},
  volume={27 10},
  pages={
          1039-51
        }
}
1. Metabolites of the cyclic bisphosphonate ester, 4-[2,2'-bis-(5,5- dimethyl-1,3,2-dioxaphosphorinan-2-yl)] butanoyl-3-fluoro-benzene (PNU-91638) in bile or urine of the male Sprague-Dawley rat were characterized by mass spectrometry. The chronically bile duct/duodenal-cannulated male rats received a single oral dose of 100 mg/kg [13C] [14C]PNU-91638. Bile and urine samples were analysed for radioactivity and profiled by hplc with radiometric and UV detection. 2. The 0-28-h bile and urine… 
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The major metabolites of the bisphosphonate ester U-91502 were isolated from the bile and urine of male Sprague-Dawley rats and identified by NMR and MS and mechanisms for the formation of metabolites A, B, and C based on metabolite structure and stability were proposed.
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