Metabolism of Tricyclic Antidepressants

@article{Rudorfer2004MetabolismOT,
  title={Metabolism of Tricyclic Antidepressants},
  author={M. Rudorfer and William Z. Potter},
  journal={Cellular and Molecular Neurobiology},
  year={2004},
  volume={19},
  pages={373-409}
}
  • M. Rudorfer, William Z. Potter
  • Published 2004
  • Biology, Medicine
  • Cellular and Molecular Neurobiology
  • Abstract1. Despite the considerable advances in the treatments available for mood disorders over the past generation, tricyclic antidepressants (TCAs) remain an important option for the pharmacotherapy of depression.2. The pharmacokinetics of TCAs are characterized by substantial presystemic first-pass metabolism, a large volume of distribution, extensive protein binding, and an elimination half-life averaging about 1 day (up to 3 days for protriptyline).3. Clearance of tricyclics is dependent… CONTINUE READING
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