Metabolism of Sesamin by CYPs and UGTs in Human Liver

@inproceedings{Sakaki2012MetabolismOS,
  title={Metabolism of Sesamin by CYPs and UGTs in Human Liver},
  author={Toshiyuki Sakaki and Kaori Yasuda and Masaki Kamakura and Eiji Munetsuna and Masanori Ohta and Shin-ichi Ikushiro},
  year={2012}
}
Sesamin is a major lignan in sesame, and its biological effects such as antioxidant effect, anti-carcinogenic effects, and suppression of hypertension have been extensively studied by many researchers. However, its metabolic pathways and metabolic enzymes in human bodies have not been identified. Recently we demonstrated that CYP2C9 was the most important cytochrome P450 isoform in human liver. Next, we focused on metabolism of sesamin mono-catechol by cytochrome P450 or UDP… CONTINUE READING

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