Metabolism of Saponins From Narthecium Ossifragum - a Plant Implicated in the Aetiology of Alveld, a Hepatogenous Photosensitization of Sheep

@article{Flyen2004MetabolismOS,
  title={Metabolism of Saponins From Narthecium Ossifragum - a Plant Implicated in the Aetiology of Alveld, a Hepatogenous Photosensitization of Sheep},
  author={A. Fl{\aa}{\o}yen and A. Wilkins},
  journal={Veterinary Research Communications},
  year={2004},
  volume={21},
  pages={335-345}
}
One sheep was dosed over 4 consecutive days with 2.1 kg of leaves and flower stems of Narthecium ossifragum before it was killed. Sarsasapogenin and smilagenin glycosides, in the ratio 9:1, were the dominant saponins present in the dosed plant material. GC-MS analyses of the free and conjugated sapogenin content of samples recovered from the sheep identified three distinct regions of metabolic activity. In the first metabolic region, in the rumen and omasum, the ingested plant saponins were… Expand
Ovine Metabolism of Saponins: Evaluation of a Method for Estimating the Ovine Uptake of Steroidal Saponins from Narthecium ossifragum
TLDR
GC-MS analysis of the free and conjugated sapogenin content in bile, urine, rumen, duodenum, jejunum, colon and rectum samples collected from the sheep, faecal samples collected on days 4–7, and dosed plant material was performed found negligible levels of deuterium-labelled sarsasapogenins were detected in the samples from the animal. Expand
Ruminal Metabolism in Sheep of Saponins from Yucca schidigera
TLDR
The metabolism of Yucca saponins was identical to that of Narthecium ossifragum sap onins, and it is suggested that Yucca sapsonins could replace N. ossIFragum Saponins for toxicity studies on the latter plant. Expand
Sapogenin Levels in Narthecium ossifragum Plants and Ovis aries Lamb Faeces during Two Alveld Outbreaks in Møre og Romsdal, Norway, 2001
TLDR
The hypothesis that saponins produced by the lily bog asphodel (Nartheciumossifragum) may be the direct cause of the hepatogenous photosensitization disease alveld seen in Norwegian lambs was investigated but the results do not support the hypothesis that a dose–response relationship exists. Expand
Toxicity testing of saponin-containing Yucca schidigera Roetzl. juice in relation to hepato- and nephrotoxicity of Narthecium ossifragum (L.) Huds.
TLDR
The results of the present study demonstrate that un-hydrolysed saponins can be absorbed from the gastrointestinal tract and the possible role of saponin in causing nephrotoxicity is discussed. Expand
Accumulation of Sapogenin Conjugates and Histological Changes in the Liver and Kidneys of Lambs Suffering from Alveld, a Hepatogenous Photosensitization Disease of Sheep Grazing Narthecium ossifragum
TLDR
Elevated plasma concentrations of urea and creatinine, and the renal histopathological changes, suggested that the photosensitized lambs had been through a phase of renal injury. Expand
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TLDR
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TLDR
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Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility—in vitro study
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