Metabolism of Perfused C14-labeled Nucleosides and Bases by the Isolated Heart.


• In addition to an intermediary role in nucleotide synthesis and degradation, purine and pyrimidine nucleosides and bases (present as natural constituents of mammalian myocardium 1) have been found to exert specific physiologic effects when administered to failing 2 " 1 and nonfailing 4 isolated hearts. In this respect, natural nucleosides and bases… (More)

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