Metabolism of N-nitrosamines by cultured human and rat esophagus.

@article{Autrup1982MetabolismON,
  title={Metabolism of N-nitrosamines by cultured human and rat esophagus.},
  author={Herman Autrup and Gary David Stoner},
  journal={Cancer research},
  year={1982},
  volume={42 4},
  pages={1307-11}
}
The metabolism of several N-nitrosamines (N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosodiethylamine, N-nitrosobenzylmethylamine, and N-nitrosopyrrolidine) in cultured human and rat esophagus has been investigated by measuring (a) CO2, (b) metabolites with an oxo group, and (c) metabolites bound to DNA. Both acyclic and cyclic N-nitrosamines were metabolized by rat esophagus. The highest level of metabolite binding was seen with N-nitrosobenzylmethylamine, an organotrophic… CONTINUE READING
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