Metabolism of N-nitrosamines by cultured human and rat esophagus.

  title={Metabolism of N-nitrosamines by cultured human and rat esophagus.},
  author={Herman Autrup and Gary David Stoner},
  journal={Cancer research},
  volume={42 4},
The metabolism of several N-nitrosamines (N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosodiethylamine, N-nitrosobenzylmethylamine, and N-nitrosopyrrolidine) in cultured human and rat esophagus has been investigated by measuring (a) CO2, (b) metabolites with an oxo group, and (c) metabolites bound to DNA. Both acyclic and cyclic N-nitrosamines were metabolized by rat esophagus. The highest level of metabolite binding was seen with N-nitrosobenzylmethylamine, an organotrophic… CONTINUE READING
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Evidence for metabolic ahydroxylation of W-nitrosopyrrolidine

  • S S.Hecht., B. Chen. C-H, D Hoffman
  • Cancer Res.,
  • 1978
Highly Influential
4 Excerpts

Organospecific carcinogenesis in the digestive tract

  • E. Druckrey
  • Topics in 1310 CANCER RESEARCH VOL. 42 on April
  • 1982
1 Excerpt

Methylation cf hamster DNA by the carcinogen N-nitroso-bis(2-oxopropyl)amine

  • Lawson, D.T.A.. Gingell. R.. Nagel, L. A. Hiñes, A Ross.
  • Cancer Lett.
  • 1981
2 Excerpts

Distribution of W-nitrosomethylbenzylamine evaluated by whole-body radioautography and densitometry

  • L Kraft.P., S. R. Tannenbaum
  • Can cer Res.,
  • 1980
1 Excerpt

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